Yes it is! Take a look at the "User Maintenance and Security" section of the User Guide here: https://www.quotewerks.com/helpfilelatest/qwhelp.htm?productdatasourcesecurity.htm
In Tools > Options > Security, ensure Enable Individual Product Data Source Security is ticked.
Then, go Products > Setup Product Sources > Select a data source you want to 'control' and click Edit.
Click Next a few times and you'll then see something like the below.
Thank you so much for your help. I must have missed this in my help searching so apologies for a RTFM question.
Is it possible to set user permissions or group security to Product Data Sources?
E.g. Product data source "A" is only accessible by Group Member = Inside Sales